Appleby has been featured in a number of music videos, such as Bon Jovi's video for "It's My Life" with Will Estes, and the 2004 video for the song "I Don't Want to Be" by Gavin De Graw, opposite Scott Mechlowicz.
She also appeared in Sense Field's music video for "Save Yourself," which is part of the Roswell soundtrack and featured in the first season DVD box set.
Description: Lucy Lambert (Shiri Appleby) has a secure job, great friends and a longtime boyfriend who has just popped the question.
The trouble is, deep down, she knows he’s not the one.
With a little help from her future self, Lucy could be headed toward the future of her dreams. Watch Dating Rules From My Future Self and find out.
Season 1, Episode 1 CC TV-PG HD SD Lucy seems to have all the answeres, a goodlooking fiance, a job at a cool web design firm, but someone keeps texting her strange messages that things aren't as great as they seem. Season 1, Episode 3 CC TV-PG HD SD What if your fiancé was a total douche and everyone knew it but you?
At the end of the year, she appeared as Charlie Wilson's press secretary in the film Charlie Wilson's War, which stars Tom Hanks and Julia Roberts.
In 2008, Appleby had a recurring role on the 15th and final season of ER (her second time on the show), playing an intern named Daria Wade.
In 2013, she was cast in the leading role in the Lifetime drama/dark comedy series Unreal, a show about the inner workings of a reality show (a show within a show), which premiered on June 1, 2015, and was produced by former The Bachelor producer, Sarah Gertrude Shapiro and writer Marti Noxon.
In Hebrew, the word shiri means either "my song" or "my poem" or simply "sing" (first person female imperative).
Appleby said her parents said that when she was born, she was like the song in their hearts.
In the summer of 2012, she starred as Lucy in the web comedy series Dating Rules from My Future Self.
She had recurring roles on both the NBC drama series Chicago Fire and the HBO comedy-drama series Girls.
Appleby began her acting career at the age of four, starting with advertisements for various products such as Cheerios and M&M's. (1989), ER (1994), Baywatch (1989), Xena: Warrior Princess (1995), 7th Heaven (1997), Beverly Hills, 90210 (1990), before landing her break-out role in the series Roswell (1999–2002), where she tried out for the roles of Isabel and Maria before landing the leading role of Liz Parker.